What makes a weapon powerful? The word powerful can be very subjective in this case. Causing massive annihilation is powerful but so is inciting fear in a prolonged and painful manner. Anything that can destroy lives and properties is powerful, conversely anything that can protect lives and properties from these 25 most powerful weapons in history is also equally powerful. There is no stopping any country or institution from proving to the world how powerful they can be whether by destroying their enemy or protecting their own.