Top 5 Best Digestive Enzymes in 2024

Posted by , Updated on November 23, 2023

Digestive enzymes are an essential part of our digestive system. They are responsible for breaking down the food we eat into smaller, more manageable pieces that our body can absorb. However, some people may not produce enough digestive enzymes, leading to discomfort, bloating, and other digestive issues. This is where digestive enzyme supplements come in.

Digestive enzyme supplements are designed to help people who have difficulty digesting certain foods. They contain a blend of enzymes that help break down carbohydrates, proteins, and fats. These supplements can be especially helpful for people who have lactose intolerance, gluten sensitivity, or other digestive disorders.

When choosing the best digestive enzyme supplement, it’s essential to consider the specific enzymes included in the product. Different enzymes are responsible for breaking down different types of food. For example, lactase helps break down lactose, the sugar found in milk, while protease breaks down proteins. It’s also crucial to consider the potency of the enzymes and the dosage instructions.

We spent hours researching and testing the top digestive enzyme supplements on the market to identify the ones that provide the most comprehensive digestive support. In the following sections, we’ll share our findings on the best digestive enzyme supplements available and what to look for when choosing the right one for you.

Best Digestive Enzymes

We understand that digestive issues can be uncomfortable and frustrating. That’s why we’ve researched and tested various digestive enzyme supplements to bring you our top picks for the best digestive enzymes on the market. Our list includes products that are effective, affordable, and made with high-quality ingredients. Whether you’re dealing with occasional digestive discomfort or a chronic condition, we’ve got you covered. Check out our top recommendations below.

1. Physician’s CHOICE Digestive Enzymes

If you’re looking for a way to improve your digestive health, Physician’s CHOICE Digestive Enzymes might be the solution you need.


  • With 16 beneficial enzymes, these capsules can digest proteins, carbs, fruits, veggies, beans, dairy, and fats, making them suitable for all diets.
  • The prebiotics and probiotics in the formula work together with the digestive enzymes to provide dual-action relief from mealtime discomfort.
  • The three soil-based probiotic strains in the formula are specifically selected for their ability to survive the harsh gut environment.


  • Some users may experience uncomfortable bathroom breaks if they take one capsule with each meal.
  • The capsules may not be effective for everyone, depending on individual digestive issues.
  • The recommended dosage of one capsule with each meal may be inconvenient for some users.

Our team found that Physician’s CHOICE Digestive Enzymes were effective in reducing bloating and discomfort after meals. The capsules are easy to swallow and have no taste. However, some users may need to adjust the dosage to avoid discomfort.

In addition to being science-backed, the product is 3rd-party tested for purity and potency, making it a safe choice for anyone looking to improve their digestive health.

Overall, we recommend Physician’s CHOICE Digestive Enzymes for anyone looking for a natural way to improve their digestive health and reduce mealtime discomfort.

2. Doctor’s BEST Digestive Enzymes

We highly recommend Doctor’s BEST Digestive Enzymes for anyone looking to improve their digestive health. This uniquely formulated, full-spectrum high potency digestive enzyme blend is designed to complement and support the body’s own digestive capacities.


  • Provides enzymes to aid in the digestion of fats, proteins, and carbohydrates present in cooked and raw food.
  • Contains friendly bacteria to promote optimal intestinal health.
  • Enzyme supplements containing a full-spectrum of digestive capacity can reduce the need for the pancreas to manufacture enzymes and free up the body to devote its energies to the daily maintenance of other critical bodily organs and systems.


  • Exposure to heat or sunlight may lead to melting/damage of the product.
  • During the summer months, products may arrive warm.

Doctor’s BEST Digestive Enzymes is a unique formula that supplies the added support of alpha-galactosidase and beta-glucanase to break down vegetables, beans, and grains. It also supplies enzymes such as glucoamylase and invertase to assist with the digestion of sugars. In addition, this complete formula contains friendly probiotic bacteria to uniquely promote optimal intestinal health.

The product is formulated with bromelain, protease, pancreatin, and papain, enzymes that help to optimize the breakdown of fats, carbohydrates, and protein. Lipase, the main enzyme that functions to break down lipids and improve fat utilization, is also included in this product.

Overall, Doctor’s BEST Digestive Enzymes is a great product for anyone looking to improve their digestive health. The product is non-GMO, gluten-free, soy-free, and vegetarian, making it a great option for those with dietary restrictions.

3. Zenwise Digestive Enzymes – Probiotic Multi Enzyme with Probiotics and Prebiotics for Digestive Health and Bloating Relief for Women and Men, Enzymes for Gut Health – 180 Count

If you are looking for a digestive enzyme supplement to help you find relief from occasional bloating, gas, and discomfort, Zenwise Digestive Enzymes with Pre & Probiotics Supplements could be an excellent choice.


  • This supplement is formulated with plant-powered pills that are AVA-Certified Vegetarian.
  • The advanced enzyme + prebiotic, probiotic non-GMO formula tackles hard-to-digest foods and helps with regularity, digestive, and immune health.
  • Zenwise Digestive Enzymes includes a clinically proven De111 Probiotic that is guaranteed to arrive alive and work within hours in the small intestine, where 90% of nutrient absorption occurs and 70% of the immune system resides.


  • Some users have reported stomach ache and gas after taking this supplement with every meal.
  • It may take a while to see any significant results.
  • The capsules are relatively large and may be difficult to swallow for some people.

In our experience, Zenwise Digestive Enzymes with Pre & Probiotics Supplements is an excellent supplement for those looking to improve their gut health. The supplement contains a blend of digestive enzymes, prebiotics, and probiotics that help with digestion and regularity. The inclusion of botanicals like turmeric, ginger, green papaya, inulin, apple pectin, bladderwrack, fennel, and wakame also aids gut health and stomach comfort.

We recommend taking one capsule before each meal to experience digestive delight. It is also worth noting that this supplement comes in a 180 serving supply, making it an excellent value for money. If you are looking to improve your gut health, Zenwise Digestive Enzymes with Pre & Probiotics Supplements is definitely worth considering.

4. Garden of Life Dr Formulated Digestive Enzymes with Papain, Bromelain, Lipase for Digestion & Nutrient Absorption – Organic Digest+ – Vegan, Gluten-Free, Non-GMO, Tropical Fruit Flavor, 90 Chewables

If you’re looking for a full-spectrum vegan digestive enzyme formula that includes organic whole foods and is Non-GMO Project Verified, then Garden of Life’s Organic Digest is a great option.


  • Organic Digest offers 29 Certified Organic fruits and vegetables plus a select blend of 13 powerful digestive enzymes including amylase, bromelain, and lactase to help with digestion after meals.
  • Made from whole foods, this full spectrum plant-based enzyme formula aids the digestion of proteins, fats, and carbs. We’ve also included prebiotic fiber from Organic Acacia to support the good bacteria in your gut.
  • Backed by science, the Dr. Formulated Organic Digest is the first-ever Certified Organic and Non-GMO digestive enzyme formula that is made from real food and is delivered using Clean Tablet Technology to ensure optimal nutrient absorption.


  • Some users may find the tropical flavor too strong.
  • The tablets are quite large and may be difficult to swallow for some individuals.
  • Organic Digest may not be suitable for individuals with certain food allergies or intolerances due to the presence of certain fruits and vegetables in the formula.

We’ve found that Garden of Life’s Organic Digest provides a convenient and effective solution for those looking to improve their digestion and nutrient absorption. The tropical flavor is a nice touch, and the tablets are easy to take on the go. Plus, the inclusion of prebiotic fiber from Organic Acacia helps support the good bacteria in your gut.

In our experience, the only downside is that the tablets are quite large, which may be difficult for some individuals to swallow. Additionally, those with certain food allergies or intolerances may need to exercise caution due to the presence of certain fruits and vegetables in the formula. Overall, we would recommend giving Organic Digest a try if you’re in need of a digestive enzyme supplement.

5. NOW Supplements, Super Enzymes

We highly recommend NOW Supplements, Super Enzymes for those looking for a comprehensive blend of enzymes that support healthy digestion. With its unique blend of bromelain, ox bile, pancreatin, and papain, this supplement helps optimize the breakdown of fats, carbohydrates, and protein, allowing for better nutrient absorption.


  • Helps with healthy digestion
  • Optimizes nutrient availability
  • Certified soy-free, gluten-free, and keto-friendly


  • May melt or get damaged if exposed to heat or sunlight during delivery
  • May cause heartburn in some individuals
  • Slightly more expensive than other digestive enzyme supplements

Overall, we believe NOW Supplements, Super Enzymes is a great investment for those looking to improve their digestion and nutrient absorption. This supplement is easy to take, with just one capsule needed per meal. Plus, it is GMP Quality Assured, ensuring that every aspect of the manufacturing process has been examined for stability, potency, and product formulation.

If you struggle with digestive issues or simply want to optimize your nutrient absorption, NOW Supplements, Super Enzymes is definitely worth considering.

Buying Guide

When it comes to choosing the best digestive enzyme supplement, there are a few factors to consider. Here are some key features to look for:

Enzyme Types

Look for a supplement that contains a variety of enzymes to help break down different types of food. Common enzymes include protease for breaking down protein, lipase for breaking down fat, and amylase for breaking down carbohydrates.


Check the dosage instructions carefully to ensure you are taking the correct amount of enzymes for your needs. Some supplements may require multiple capsules per serving, while others may be taken with each meal.


Choose a supplement from a reputable brand that uses high-quality ingredients and follows good manufacturing practices. Look for products that have been independently tested for purity and potency.


If you have food allergies or sensitivities, be sure to check the label carefully to make sure the supplement does not contain any ingredients that could trigger a reaction.


Consider the formulation of the supplement, including whether it is in capsule or tablet form, and whether it is designed for immediate or delayed release. Some supplements may also include additional ingredients such as probiotics or prebiotics to support digestive health.

Overall, the best digestive enzyme supplement for you will depend on your individual needs and preferences. By considering these key features, you can make an informed decision and choose a high-quality supplement that supports healthy digestion.

Frequently Asked Questions

What are the benefits of taking digestive enzyme supplements?

Digestive enzyme supplements can help improve digestion, reduce bloating, and alleviate discomfort after meals. They can also help individuals who have difficulty breaking down certain foods, such as those with lactose intolerance or gluten sensitivity.

What are the differences between natural and tablet digestive enzymes?

Natural digestive enzymes are derived from food sources, while tablet digestive enzymes are typically synthetic and produced in a laboratory. Natural enzymes are generally considered safer and more effective, as they are better tolerated by the body and contain a wider range of enzymes.

Which digestive enzyme supplement is best for GERD?

Individuals with GERD may benefit from taking digestive enzyme supplements that contain enzymes like amylase, lipase, and protease. It is important to consult with a healthcare professional before taking any supplement to ensure it is safe and effective for your specific needs.

What are the best digestive enzymes for constipation relief?

Digestive enzyme supplements that contain enzymes like cellulase, lactase, and alpha-galactosidase may help alleviate constipation by breaking down complex carbohydrates and other indigestible fibers. Again, it is important to consult with a healthcare professional before taking any supplement.

How do digestive enzymes aid in bodybuilding?

Digestive enzymes can help bodybuilders break down and absorb protein more efficiently, which can aid in muscle growth and recovery. Protease is a particularly important enzyme for bodybuilders, as it helps break down protein into amino acids.

Do digestive enzyme supplements really improve digestion?

While digestive enzyme supplements may help improve digestion in some individuals, they are not a cure-all for digestive issues. It is important to maintain a healthy diet and lifestyle, and to consult with a healthcare professional if you are experiencing persistent digestive symptoms.